DIPG Clinical Trials

Phase I/ii Open Label, Dose Escalation Trial To Determine The Mtd, Safety, Pk And Efficacy Of Afatinib Monotherapy In Children Aged ≥1 Year To <18 Years With Recurrent/refractory Neuroectodermal Tumours, Rhabdomyosarcoma And/or Other Solid Tumours With Known Erbb Pathway Deregulation Regardless Of Tumour Histology
Last Updated: 2020-07-02
Originally Posted: 2015-05-04

Convection-Enhanced Delivery of 124I-Omburtamab for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy
Last Updated: 2020-06-28
Originally Posted: 2011-12-29

Volitinib in Treating Participants With Recurrent or Refractory Primary CNS Tumors
Last Updated: 2020-06-20
Originally Posted: 2018-07-24

A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma
Last Updated: 2020-06-20
Originally Posted: 2018-07-20

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma
Last Updated: 2020-06-11
Originally Posted: 2015-02-09

GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas(DIPG) & Spinal Diffuse Midline Glioma(DMG)
Last Updated: 2020-06-11
Originally Posted: 2019-12-10

Immune Modulatory DC Vaccine Against Brain Tumor
Last Updated: 2020-06-10
Originally Posted: 2019-04-11

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
Last Updated: 2020-06-09
Originally Posted: 2018-10-09

Fimepinostat in Treating Brain Tumors in Children and Young Adults
Last Updated: 2020-06-09
Originally Posted: 2019-03-26

Study of Re-irradiation at Relapse Versus RT and Multiple Elective rt Courses
Last Updated: 2020-06-08
Originally Posted: 2018-05-14

H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas
Last Updated: 2020-06-04
Originally Posted: 2016-11-02

International Cooperative Phase Iii Trial Of The Hit-hgg Study Group For The Treatment Of High Grade Glioma, Diffuse Intrinsic Pontine Glioma, And Gliomatosis Cerebri In Children And Adolescents < 18 Years.
Last Updated: 2020-05-27
Originally Posted: 2016-11-21

INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas
Last Updated: 2020-05-27
Originally Posted: 2020-02-27

Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)
Last Updated: 2020-04-22
Originally Posted: 2018-01-04

Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors
Last Updated: 2020-04-01
Originally Posted: 2015-12-15

ONC201 in Pediatric H3 K27M Gliomas
Last Updated: 2020-03-31
Originally Posted: 2018-01-23

A Study of Low Dose Bevacizumab With Conventional Radiotherapy Alone in Diffuse Intrinsic Pontine Glioma
Last Updated: 2020-03-20
Originally Posted: 2020-01-07

Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma
Last Updated: 2020-03-12
Originally Posted: 2018-11-02

Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22
Last Updated: 2020-03-06
Originally Posted: 2013-06-19

Trial of Panobinostat in Children With Diffuse Intrinsic Pontine Glioma
Last Updated: 2020-03-03
Originally Posted: 2016-02-22

Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers
Last Updated: 2020-02-28
Originally Posted: 2018-05-25

Dose Escalation Study of CLR 131 in Children and Adolescents With Relapsed or Refractory Malignant Tumors Including But Not Limited to Neuroblastoma, Rhabdomyosarcoma, Ewings Sarcoma, and Osteosarcoma
Last Updated: 2020-02-24
Originally Posted: 2018-03-20

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
Last Updated: 2020-02-21
Originally Posted: 2019-11-26

Phase I Study of APX005M in Pediatric CNS Tumors
Last Updated: 2020-02-20
Originally Posted: 2017-12-15

C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)
Last Updated: 2020-02-20
Originally Posted: 2019-09-20

CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas
Last Updated: 2020-02-18
Originally Posted: 2020-02-07

REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma
Last Updated: 2020-02-03
Originally Posted: 2018-09-17

International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository
Last Updated: 2020-01-28
Originally Posted: 2017-03-08

Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG
Last Updated: 2019-10-17
Originally Posted: 2019-08-02

Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma
Last Updated: 2019-09-25
Originally Posted: 2016-11-29

Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors
Last Updated: 2019-09-23
Originally Posted: 2017-12-05

Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors
Last Updated: 2019-09-05
Originally Posted: 2015-12-27

CED With Irinotecan Liposome Injection Using Real Time Imaging in Children With Diffuse Intrinsic Pontine Glioma (DIPG)
Last Updated: 2019-08-07
Originally Posted: 2017-03-16

Diffuse Brainstem Glioma Tumour Study: developing new treatment strategies for Diffuse Pontine Glioma
Last Updated: 2019-05-02
Originally Posted: 2012-10-31

Re-Irradiation of Progressive or Recurrent DIPG
Last Updated: 2019-04-22
Originally Posted: 2017-04-19

Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma
Last Updated: 2019-03-27
Originally Posted: 2010-04-19

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas
Last Updated: 2019-03-22
Originally Posted: 2013-04-16

Inform2 Exploratory Multinational Phase I/ii Combination Study Of Nivolumab And Entinostat In Children And Adolescents With Refractory High-risk Malignancies
Last Updated: 2019-03-18
Originally Posted: 2019-03-18

Hypofractionated Radiotherapy for Recurrent DIPG
Last Updated: 2019-02-13
Originally Posted: 2019-02-12

A study to evaluate the safety,tolerability and pharmacokinetics of ACT001 in children with advanced brain and solid tumors
Last Updated: 2018-11-28
Originally Posted: 2018-11-05

International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)
Last Updated: 2018-08-07
Originally Posted: 2017-08-04

Biological Medicine For Diffuse Intrinsic Pontine Glioma (dipg) Eradication
Last Updated: 2018-08-02
Originally Posted: 2018-08-02

Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication
Last Updated: 2018-07-20
Originally Posted: 2014-08-29

11c-erlotinib Brain Uptake In Diffuse Intrinsic Pontine Glioma Imaged By Pet
Last Updated: 2018-05-04
Originally Posted: 2018-05-04

Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Glioma
Last Updated: 2018-02-14
Originally Posted: 2016-04-27

A Phase 2 Clinical Study Of Pomalidomide (cc-4047) Monotherapy For Children And Young Adults With Recurrent Or Progressive Primary Brain Tumors.
Last Updated: 2018-01-30
Originally Posted: 2018-01-30

A Phase 2 Clinical Study Of Pomalidomide (cc-4047) Monotherapy For Children And Young Adults With Recurrent Or Progressive Primary Brain Tumors.
Last Updated: 2017-09-26
Originally Posted: 2017-09-26

Phase Ib /ii Clinical Trial Of Nivolumab Monotherapy And Nivolumab In Combination With Ipilimumab In Pediatric Subjects With High Grade Primary Cns Malignancies
Last Updated: 2017-08-01
Originally Posted: 2017-08-01

Biological Medicine For Diffuse Intrinsic Pontine Glioma (dipg) Eradication
Last Updated: 2017-08-01
Originally Posted: 2017-08-01

A Phase 2 Clinical Study Of Pomalidomide (cc-4047) Monotherapy For Children And Young Adults With Recurrent Or Progressive Primary Brain Tumors.
Last Updated: 2017-07-27
Originally Posted: 2017-07-27

Phase Ib /ii Clinical Trial Of Nivolumab Monotherapy And Nivolumab In Combination With Ipilimumab In Pediatric Subjects With High Grade Primary Cns Malignancies
Last Updated: 2017-07-11
Originally Posted: 2017-07-11

Phase Ib /ii Clinical Trial Of Nivolumab Monotherapy And Nivolumab In Combination With Ipilimumab In Pediatric Subjects With High Grade Primary Cns Malignancies
Last Updated: 2017-06-19
Originally Posted: 2017-06-19

Phase Ib /ii Clinical Trial Of Nivolumab Monotherapy And Nivolumab In Combination With Ipilimumab In Pediatric Subjects With High Grade Primary Cns Malignancies
Last Updated: 2017-04-28
Originally Posted: 2017-04-28

Phase Ib /ii Clinical Trial Of Nivolumab Monotherapy And Nivolumab In Combination With Ipilimumab In Pediatric Subjects With High Grade Primary Cns Malignancies
Last Updated: 2017-04-17
Originally Posted: 2017-04-17

Biological Medicine For Diffuse Intrinsic Pontine Glioma (dipg) Eradication (biomede)
Last Updated: 2016-11-25
Originally Posted: 2016-11-25

A Phase I/ii, Multicenter, Open-label, Dose-escalation Study Of The Safety And Pharmacokinetics Of Cobimetinib In Pediatric And Young Adult Patients With Previously Treated Solid Tumors
Last Updated: 2016-10-06
Originally Posted: 2016-10-06

Phase I Trial Of Dnx-2401 For Diffuse Intrinsic Pontine Glioma Newly Diagnosed In Pediatric Patients.
Last Updated: 2016-08-18
Originally Posted: 2016-08-18

A Phase I/ii, Multicenter, Open-label, Dose-escalation Study Of The Safety And Pharmacokinetics Of Cobimetinib In Pediatric And Young Adult Patients With Previously Treated Solid Tumors
Last Updated: 2016-08-17
Originally Posted: 2016-08-17

Biological Medicine For Diffuse Intrinsic Pontine Glioma (dipg) Eradication
Last Updated: 2016-06-22
Originally Posted: 2016-06-22

A Phase I/ii, Multicenter, Open-label, Dose-escalation Study Of The Safety And Pharmacokinetics Of Cobimetinib In Pediatric And Young Adult Patients With Previously Treated Solid Tumors
Last Updated: 2016-06-07
Originally Posted: 2016-06-07

A Phase I/ii, Multicenter, Open-label, Dose-escalation Study Of The Safety And Pharmacokinetics Of Cobimetinib In Pediatric And Young Adult Patients With Previously Treated Solid Tumors
Last Updated: 2016-04-22
Originally Posted: 2016-04-22

A Phase I/ii, Multicenter, Open-label, Dose-escalation Study Of The Safety And Pharmacokinetics Of Cobimetinib In Pediatric And Young Adult Patients With Previously Treated Solid Tumors
Last Updated: 2016-04-12
Originally Posted: 2016-04-12

A Phase I/ii, Multicenter, Open-label, Dose-escalation Study Of The Safety And Pharmacokinetics Of Cobimetinib In Pediatric And Young Adult Patients With Previously Treated Solid Tumors
Last Updated: 2016-03-15
Originally Posted: 2016-03-15

Phase Ib Clinical Trial On The Safety Of Immunotherapy With Autologous Dendritic Cells Primed With Lysate Allogeneic Tumor Lines In Patients With Diffuse Intrinsic Pontine Glioma ( Dipg )
Last Updated: 2016-01-13
Originally Posted: 2016-01-13

Phase I Open Label, Dose Escalation Trial To Determine The Mtd, Safety, Pk And Efficacy Of Afatinib Monotherapy In Children Aged 2 Years To <18 Years With Recurrent/refractory Neuroectodermal Tumours, Rhabdomyosarcoma And/or Other Solid Tumours With Known Erbb Pathway Deregulation Regardless Of Tumour Histology
Last Updated: 2015-11-23
Originally Posted: 2015-11-23

Biological Medicine For Diffuse Intrinsic Pontine Glioma (dipg) Eradication
Last Updated: 2015-09-16
Originally Posted: 2015-09-16

Phase I/ii Open Label, Dose Escalation Trial To Determine The Mtd, Safety, Pk And Efficacy Of Afatinib Monotherapy In Children Aged ≥ 1 Year To <18 Years With Recurrent/refractory Neuroectodermal Tumours, Rhabdomyosarcoma And/or Other Solid Tumours With Known Erbb Pathway Deregulation Regardless Of Tumour Histology
Last Updated: 2015-02-11
Originally Posted: 2015-02-11

A Comprehensive And Targeted Therapy Approach In Pediatric Malignant Pontine Gliomas
Last Updated: 2010-06-09
Originally Posted: 2010-06-09