DIPG / DMG Clinical Trials

Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers
Last Updated: 2022-06-29
Originally Posted: 2018-05-25

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)
Last Updated: 2022-06-29
Originally Posted: 2021-10-28

Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors
Last Updated: 2022-06-28
Originally Posted: 2018-07-24

A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling
Last Updated: 2022-06-24
Originally Posted: 2021-02-09

A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma
Last Updated: 2022-06-23
Originally Posted: 2018-07-20

GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas(DIPG) & Spinal Diffuse Midline Glioma(DMG)
Last Updated: 2022-06-22
Originally Posted: 2019-12-10

Phase I Study of APX005M in Pediatric CNS Tumors
Last Updated: 2022-06-21
Originally Posted: 2017-12-15

A Study of Abemaciclib (LY2835219) in Combination With Temozolomide and Irinotecan and Abemaciclib in Combination With Temozolomide in Children and Young Adult Participants With Solid Tumors
Last Updated: 2022-06-21
Originally Posted: 2020-01-22

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma
Last Updated: 2022-06-17
Originally Posted: 2021-04-19

A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG)
Last Updated: 2022-06-16
Originally Posted: 2021-02-17

Combination Therapy for the Treatment of Diffuse Midline Gliomas
Last Updated: 2022-06-16
Originally Posted: 2021-08-10

rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG
Last Updated: 2022-06-08
Originally Posted: 2021-05-24

A Phase 1/2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2 in Patients With DIPG
Last Updated: 2022-06-07
Originally Posted: 2021-10-11

International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)
Last Updated: 2022-06-02
Originally Posted: 2017-08-04

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma
Last Updated: 2022-06-02
Originally Posted: 2021-07-20

HRQL and Symptom Assessment for Patients With DIPG or Recurrent and Re-irradiated Brain Tumours and Their Caregivers
Last Updated: 2022-05-17
Originally Posted: 2020-11-17

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
Last Updated: 2022-05-16
Originally Posted: 2018-10-09

Magrolimab in Children and Adults With Recurrent or Progressive Malignant Brain Tumors
Last Updated: 2022-05-09
Originally Posted: 2021-12-14

T Cells Expressing HER2-specific Chimeric Antigen Receptors(CAR) for Patients With HER2-Positive CNS Tumors
Last Updated: 2022-05-03
Originally Posted: 2015-05-11

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
Last Updated: 2022-05-02
Originally Posted: 2019-11-26

Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)
Last Updated: 2022-04-29
Originally Posted: 2018-01-04

A Study of Low Dose Bevacizumab With Conventional Radiotherapy Alone in Diffuse Intrinsic Pontine Glioma
Last Updated: 2022-04-28
Originally Posted: 2020-01-07

ONC206 for Treatment of Newly Diagnosed, or Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors (PNOC 023)
Last Updated: 2022-04-27
Originally Posted: 2021-01-26

9-ING-41 in Pediatric Patients With Refractory Malignancies.
Last Updated: 2022-04-26
Originally Posted: 2020-01-20

PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
Last Updated: 2022-04-20
Originally Posted: 2021-04-06

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas
Last Updated: 2022-04-05
Originally Posted: 2013-04-16

Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors
Last Updated: 2022-04-01
Originally Posted: 2015-12-15

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors
Last Updated: 2022-04-01
Originally Posted: 2018-02-09

Fimepinostat in Treating Brain Tumors in Children and Young Adults
Last Updated: 2022-03-31
Originally Posted: 2019-03-26

Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG
Last Updated: 2022-03-11
Originally Posted: 2019-08-02

CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas
Last Updated: 2022-03-08
Originally Posted: 2020-02-07

ONC201 in Pediatric H3 K27M Gliomas
Last Updated: 2022-03-01
Originally Posted: 2018-01-23

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
Last Updated: 2022-03-01
Originally Posted: 2020-09-01

ONC201 in Adults With Recurrent H3 K27M-mutant Glioma
Last Updated: 2022-03-01
Originally Posted: 2017-08-01

A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors
Last Updated: 2022-02-25
Originally Posted: 2021-11-04

Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma
Last Updated: 2022-02-22
Originally Posted: 2018-11-02

C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)
Last Updated: 2022-02-07
Originally Posted: 2019-09-20

Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma
Last Updated: 2022-01-31
Originally Posted: 2016-11-29

Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study
Last Updated: 2022-01-31
Originally Posted: 2021-10-01

REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma
Last Updated: 2022-01-27
Originally Posted: 2018-09-17

A Phase 1/2, Single-arm Study To Evaluate The Safety, Pharmacokinetics, And Antitumor Activity Of Avapritinib In Pediatric Patients With Solid Tumors Dependent On Kit Or Pdgfra Signaling
Last Updated: 2022-01-26
Originally Posted: 2022-01-26

Open-label Study Investigating of OKN-007 Combined With Temozolomide in Patients With Recurrent Glioblastoma
Last Updated: 2021-12-28
Originally Posted: 2020-05-06

Re-Irradiation of Progressive or Recurrent DIPG
Last Updated: 2021-12-14
Originally Posted: 2017-04-19

Dose Escalation Study of CLR 131 in Children, Adolescents, and Young Adults With Relapsed or Refractory Malignant Tumors Including But Not Limited to Neuroblastoma, Rhabdomyosarcoma, Ewings Sarcoma, and Osteosarcoma
Last Updated: 2021-11-30
Originally Posted: 2018-03-20

Oral AMXT 1501 Dicaprate in Combination With DFMO
Last Updated: 2021-11-16
Originally Posted: 2018-04-04

Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
Last Updated: 2021-11-03
Originally Posted: 2021-11-03

Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma
Last Updated: 2021-11-01
Originally Posted: 2010-04-19

Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors
Last Updated: 2021-09-17
Originally Posted: 2015-12-27

Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma
Last Updated: 2021-09-13
Originally Posted: 2021-04-30

Study of Re-irradiation at Relapse Versus RT and Multiple Elective rt Courses
Last Updated: 2021-09-03
Originally Posted: 2018-05-14

Clinical Trial to Assess the Safety and Efficacy of AloCELYVIR With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Combination With Radiotherapy or Medulloblastoma in Monotherapy
Last Updated: 2021-08-21
Originally Posted: 2021-02-08

Multi-antigen T Cell Infusion Against Neuro-oncologic Disease
Last Updated: 2021-07-15
Originally Posted: 2018-08-28

AflacST1901: Peds WP1066
Last Updated: 2021-07-13
Originally Posted: 2020-04-02

Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma
Last Updated: 2021-07-06
Originally Posted: 2021-02-03

Hypofractionated Radiotherapy for Recurrent DIPG
Last Updated: 2021-07-01
Originally Posted: 2019-02-12

International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository
Last Updated: 2021-06-18
Originally Posted: 2017-03-08

Convection-Enhanced Delivery of 124I-Omburtamab for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy
Last Updated: 2021-06-08
Originally Posted: 2011-12-29

Dipgen – Multicenter, Open Label Study Using Molecularly Determined Targeted Therapies In Children 3-18 Years Of Age With Dipg (diffuse Intrinsic Pontine Glioma- Dipg)
Last Updated: 2021-06-07
Originally Posted: 2021-06-07

International Cooperative Phase Iii Trial Of The Hit-hgg Study Group For The Treatment Of High Grade Glioma, Diffuse Intrinsic Pontine Glioma, And Gliomatosis Cerebri In Children And Adolescents < 18 Years.
Last Updated: 2021-05-31
Originally Posted: 2021-05-31

Nimotuzumab in Combined With Concurrent Radiochemotherapy in the Treatment of Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Children
Last Updated: 2021-04-21
Originally Posted: 2020-08-26

Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22
Last Updated: 2021-04-16
Originally Posted: 2013-06-19

Diagnostic And Clinical Value Of 64cucl2 In Hgg/dipg
Last Updated: 2021-04-16
Originally Posted: 2021-04-16

Diffuse Brainstem Glioma Tumour Study: developing new treatment strategies for Diffuse Pontine Glioma
Last Updated: 2020-12-01
Originally Posted: 2012-10-31

Phase 2 Open Label Randomized Study Of Radiotherapy, Concomitant Nimotuzumab And Vinorelbine And Re-irradiation At Relapse Versus Radiotherapy And Multiple Elective Radiotherapy Courses With Concomitant Vinorelbine And Nimotuzumab For Newly Diagnosed Childhood And Adolescence Diffuse Intrinsic Pontine Glioma (dipg)
Last Updated: 2020-11-04
Originally Posted: 2020-11-04

INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies (INFORM2 NivEnt)
Last Updated: 2020-09-15
Originally Posted: 2019-12-02

Immune Modulatory DC Vaccine Against Brain Tumor
Last Updated: 2020-06-10
Originally Posted: 2019-04-11

International Cooperative Phase Iii Trial Of The Hit-hgg Study Group For The Treatment Of High Grade Glioma, Diffuse Intrinsic Pontine Glioma, And Gliomatosis Cerebri In Children And Adolescents < 18 Years.
Last Updated: 2020-05-27
Originally Posted: 2016-11-21

Inform2 Exploratory Multinational Phase I/ii Combination Study Of Nivolumab And Entinostat In Children And Adolescents With Refractory High-risk Malignancies
Last Updated: 2020-03-31
Originally Posted: 2020-03-31

Inform2 Exploratory Multinational Phase I/ii Combination Study Of Nivolumab And Entinostat In Children And Adolescents With Refractory High-risk Malignancies
Last Updated: 2020-03-26
Originally Posted: 2020-03-26

Inform2 Exploratory Multinational Phase I/ii Combination Study Of Nivolumab And Entinostat In Children And Adolescents With Refractory High-risk Malignancies
Last Updated: 2019-03-18
Originally Posted: 2019-03-18

Inform2 Exploratory Multinational Phase I/ii Combination Study Of Nivolumab And Entinostat In Children And Adolescents With Refractory High-risk Malignancies
Last Updated: 2019-02-08
Originally Posted: 2019-02-08

A study to evaluate the safety,tolerability and pharmacokinetics of ACT001 in children with advanced brain and solid tumors
Last Updated: 2018-11-28
Originally Posted: 2018-11-05

Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication
Last Updated: 2018-07-20
Originally Posted: 2014-08-29

11c-erlotinib Brain Uptake In Diffuse Intrinsic Pontine Glioma Imaged By Pet
Last Updated: 2018-05-04
Originally Posted: 2018-05-04

A Phase 2 Clinical Study Of Pomalidomide (cc-4047) Monotherapy For Children And Young Adults With Recurrent Or Progressive Primary Brain Tumors.
Last Updated: 2018-01-30
Originally Posted: 2018-01-30

Biological Medicine For Diffuse Intrinsic Pontine Glioma (dipg) Eradication
Last Updated: 2017-08-01
Originally Posted: 2017-08-01

Phase I Trial Of Dnx-2401 For Diffuse Intrinsic Pontine Glioma Newly Diagnosed In Pediatric Patients.
Last Updated: 2016-08-18
Originally Posted: 2016-08-18

Biological Medicine For Diffuse Intrinsic Pontine Glioma (dipg) Eradication
Last Updated: 2016-06-22
Originally Posted: 2016-06-22

Phase Ib Clinical Trial On The Safety Of Immunotherapy With Autologous Dendritic Cells Primed With Lysate Allogeneic Tumor Lines In Patients With Diffuse Intrinsic Pontine Glioma ( Dipg )
Last Updated: 2016-01-13
Originally Posted: 2016-01-13

Biological Medicine For Diffuse Intrinsic Pontine Glioma (dipg) Eradication
Last Updated: 2015-09-16
Originally Posted: 2015-09-16

A Comprehensive And Targeted Therapy Approach In Pediatric Malignant Pontine Gliomas
Last Updated: 2010-06-09
Originally Posted: 2010-06-09